Long or Restrictive Duct Run
Rooms farthest from the air handler get the least conditioned air because the duct path has the most pressure drop along the way. Common for upstairs back rooms or rooms over garages with long runs through attics.
Hold your hand at the supply vent. If airflow is significantly weaker than rooms closer to the unit, the run is the issue.
Several fixes ranging from cheap to expensive: (1) Adjust dampers to redirect more air to weak rooms (free), (2) Install a booster fan in the problem duct ($50-150), (3) Reroute or enlarge ductwork (contractor job).